DCAF6

Across TCGA pan-cancer cohorts, DCAF6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DCAF6 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DCAF6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCAF6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

ACC, LGG, and KIRP are the cancer types where DCAF6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.267	0.655	<.001	59	view →
LGG	OS	Median	All	0.747	0.866	<.001	40	view →
KIRP	DFS	Quartile	All	0.821	0.943	.005	33	view →
KIRC	OS	Median	All	0.698	0.561	.002	28	view →
MESO	OS	Median	All	0.506	0.284	.002	27	view →
HNSC	DFS	Quartile	IV	0.505	0.262	.007	26	view →
UVM	DFS	Quartile	II,III,IV	0.318	0.793	.005	24	view →
STAD	DFS	Median	All	0.487	0.629	.010	18	view →
BRCA	DFS	Median	III,IV	0.850	0.736	.007	13	view →
LUSC	DFS	Median	All	0.792	0.696	.008	12	view →
CHOL	DFS	Median	All	0.727	0.227	.012	12	view →
BLCA	DFS	Quartile	II,III,IV	0.446	0.606	.031	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DCAF6–ACC (DFS)

Open the ACC breakdown →