DCAF6

Across TCGA pan-cancer cohorts, DCAF6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DCAF6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DCAF6 RNA is repressed in tumor relative to normal tissue. In most cancer types DCAF6 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where DCAF6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCAF6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.379	<.001	10	view →
KIRC	Female	All	+0.480	<.001	9	view →
KIRP	All	II,III,IV	+0.521	.002	7	view →
LIHC	Male	All	+0.815	<.001	6	view →
BRCA	All	All	+0.323	<.001	4	view →
CHOL	All	All	+1.406	<.001	3	view →
LUSC	All	All	+0.351	<.001	3	view →
UCEC	All	IV	−1.435	.016	2	view →
PRAD	All	All	+0.439	<.001	2	view →
LUAD	All	IV	−0.304	.011	2	view →
HNSC	Female	All	+0.459	.046	1	view →
THCA	All	All	−0.157	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DCAF6–COAD

Open the COAD breakdown →