DCAF6

Across TCGA pan-cancer cohorts, DCAF6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DCAF6 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DCAF6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCAF6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where DCAF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.581	0.898	<.001	81	view →
UCEC	DFS	Tertile	All	0.978	0.813	.014	12	view →
LSCC	OS	Tertile	III,IV	0.380	0.802	.013	4	view →
LUAD	DFS	Quartile	III,IV	0.428	1.000	.040	3	view →
HNSC	DFS	Median	III,IV	0.754	0.534	.034	1	view →
PDAC	OS	Quartile	All	0.702	0.973	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DCAF6–CCRCC (DFS)

Open the CCRCC breakdown →