DCAF5

Across TCGA pan-cancer cohorts, DCAF5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DCAF5 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher DCAF5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC, UCEC, and SKCM are the cancer types where DCAF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.043	0.819	<.001	18	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.736	0.212	.008	11	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.080	0.427	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DCAF5–LUSC (OS)

Open the LUSC breakdown →