DCAF4L2

Across TCGA patient cohorts, DCAF4L2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DCAF4L2-associated genes across cancer lineages are ASNS, PDCD4, and Notch1. Each is linked with DCAF4L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DCAF4L2-to-partner and partner-to-DCAF4L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DCAF4L2-low versus DCAF4L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF4L2→partner) and Y-score (partner→DCAF4L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.270	+2.087	.014	.004	3	4
COAD	PDCD4 →	-0.372	-1.576	.006	.018	3	3
UCEC	Notch1 →	+0.168	+2.515	<.001	<.001	3	3
COAD	Rad50 →	-0.228	-2.089	.003	.017	3	3
UCEC	RAD51 →	+0.105	+1.502	.013	.027	3	3
COAD	Stathmin →	+0.130	+1.749	.009	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ASNS by DCAF4L2 expression — UCEC

Explore this box plot interactively →