DCAF4L2

Across TCGA pan-cancer cohorts, DCAF4L2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DCAF4L2 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DCAF4L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF4L2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and TGCT show a favorable association.

KIRC, ACC, and LUSC are the cancer types where DCAF4L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.500	0.649	.005	72	view →
ACC	DFS	Tertile	III,IV	0.100	0.429	.015	39	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
SKCM	DFS	Median	IV	0.639	0.064	.002	36	view →
READ	OS	Tertile	IV	0.111	0.893	<.001	36	view →
LUAD	DFS	Tertile	IV	0.132	0.657	.001	30	view →
LGG	DFS	Median	All	0.645	0.820	<.001	28	view →
MESO	DFS	Tertile	All	0.130	0.482	.011	27	view →
UCS	OS	Tertile	IV	0.233	0.650	.010	24	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
COAD	DFS	Tertile	IV	0.159	0.503	.006	18	view →
TGCT	DFS	Tertile	All	0.844	0.576	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DCAF4L2–KIRC (OS)

Open the KIRC breakdown →