DCAF4L2

Across TCGA cell cohorts, DCAF4L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 500 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DCAF4L2-associated GO terms across cancer lineages are Cotranslational protein targeting to membrane, Regulation of inflammatory response to antigenic stimulus, and Nuclear receptor-mediated steroid hormone signaling pathway. Each is linked with DCAF4L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DCAF4L2-to-partner and partner-to-DCAF4L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cotranslational protein targeting to membrane grouped by DCAF4L2-low versus DCAF4L2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DCAF4L2→partner) and Y-score (partner→DCAF4L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cotranslational protein targeting to membrane →	+0.088	+0.071	.001	.006	3	3
SKIN	Regulation of inflammatory response to antigenic stimulus →	+0.083	+0.086	<.001	.005	3	3
SKIN	Nuclear receptor-mediated steroid hormone signaling pathway →	+0.041	+0.077	.008	.009	3	2
SKIN	Negative regulation of chondrocyte differentiation →	-0.197	-0.061	<.001	<.001	3	2
SKIN	Negative regulation of Rho protein signal transduction →	+0.111	+0.061	<.001	.003	3	2
SKIN	Interleukin-23-mediated signaling pathway →	+0.131	+0.074	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

Cotranslational protein targeting to membrane by DCAF4L2 expression — SKIN

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