DBX1

Across TCGA pan-cancer cohorts, DBX1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DBX1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where DBX1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DBX1 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

LSCC, COAD, and CCRCC are the cancer types where DBX1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBX1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.519	<.001	7	view →
COAD	All	All	+0.189	.001	6	view →
CCRCC	All	All	−0.433	<.001	4	view →
LUAD	All	All	−0.222	<.001	4	view →
OV	All	All	−1.235	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DBX1–LSCC

Open the LSCC breakdown →