DBX1

Across TCGA patient cohorts, DBX1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBX1-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Notch1. Each is linked with DBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBX1-to-partner and partner-to-DBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DBX1-low versus DBX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBX1→partner) and Y-score (partner→DBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.224	-2.584	.026	.010	3	1
UCEC	Ku80 →	+0.272	+1.920	.004	.009	3	1
UCEC	Notch1 →	+0.171	+1.750	.002	.049	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.431	-3.584	.017	.002	3	1
UCEC	PCNA →	+0.183	+2.999	.035	.035	3	1
UCEC	PDCD4 →	-0.601	-3.087	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by DBX1 expression — UCEC

Explore this box plot interactively →