DBX1

Across TCGA cell cohorts, DBX1 mutation is significantly associated with the mutation status of many other genes, with 1,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBX1-associated genes across cancer lineages are PLEKHH3, ACAD8, and COL5A2. Each is linked with DBX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DBX1-to-partner and partner-to-DBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHH3 grouped by DBX1-low versus DBX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBX1→partner) and Y-score (partner→DBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLEKHH3 →	+4.502	+5.066	.007	.007	1	3
LARGE_INTESTINE	ACAD8 →	+3.459	+3.459	.006	.006	1	3
BLOOD_Leukemia	COL5A2 →	+4.285	+5.820	<.001	<.001	1	3
LUNG_SCLC	PIK3R1 →	+4.502	+5.066	.007	.007	1	2
LUNG_SCLC	RASGRP1 →	+5.502	+5.502	.003	.003	1	2
LARGE_INTESTINE	PCNX1 →	+1.781	+3.602	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

PLEKHH3 by DBX1 expression — LUNG_SCLC

Explore this box plot interactively →