DBT

Across TCGA cell cohorts, DBT mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBT-associated genes across cancer lineages are TMIGD1, MS4A4A, and TEX101. Each is linked with DBT in more than 1 cancer types. Because this analysis shows association rather than direction, both DBT-to-partner and partner-to-DBT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMIGD1 grouped by DBT-low versus DBT-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBT→partner) and Y-score (partner→DBT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMIGD1 →	+0.020	+4.672	<.001	.002	3	1
LARGE_INTESTINE	MS4A4A →	+0.159	+2.921	<.001	.005	3	1
LARGE_INTESTINE	TEX101 →	+0.221	+3.708	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	C14orf180 →	+0.133	+2.892	<.001	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.101	+2.688	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TMIGD1 by DBT expression — BREAST

Explore this box plot interactively →