DBP

Across TCGA patient cohorts, DBP mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBP-associated genes across cancer lineages are RNU6-492P, RNU6-458P, and MIR4510. Each is linked with DBP in more than 1 cancer types. Because this analysis shows association rather than direction, both DBP-to-partner and partner-to-DBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by DBP-low versus DBP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBP→partner) and Y-score (partner→DBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
HNSC	RNU6-458P →	+0.308	+7.954	<.001	.008	3	2
CESC	MIR4510 →	+0.400	+6.342	<.001	.001	3	2
UCEC	RNA5SP100 →	+0.136	+4.253	<.001	.004	3	2
UCEC	HMGN1P20 →	+0.145	+2.351	<.001	.006	3	2
BLCA	HNRNPH3P1 →	+0.088	+5.411	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

RNU6-492P by DBP expression — HNSC

Explore this box plot interactively →