DBNL

Across TCGA pan-cancer cohorts, DBNL mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DBNL’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DBNL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DBNL is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where DBNL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBNL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.219	<.001	11	view →
HNSC	Male	IV	−0.240	<.001	8	view →
LUAD	All	II,III,IV	+0.087	.008	5	view →
PDAC	All	All	+0.171	.003	4	view →
COAD	All	III,IV	−0.073	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DBNL–CCRCC

Open the CCRCC breakdown →