DBNL

Across TCGA pan-cancer cohorts, DBNL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DBNL data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DBNL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DBNL expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

ACC, SCLC, and KICH are the cancer types where DBNL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.230	0.700	<.001	106	view →
SCLC	DFS	Median	II,III,IV	0.775	0.407	<.001	66	view →
KICH	OS	Quartile	II,III,IV	0.456	1.000	.001	61	view →
CHOL	OS	Tertile	II,III,IV	0.961	0.159	<.001	47	view →
LGG	DFS	Median	All	0.676	0.803	<.001	44	view →
COAD	DFS	Median	II,III,IV	0.694	0.812	.001	34	view →
MESO	DFS	Tertile	All	0.359	0.661	.019	32	view →
LIHC	DFS	Median	All	0.277	0.550	<.001	30	view →
PAAD	DFS	Median	II,III,IV	0.549	0.319	.001	28	view →
KIRC	DFS	Tertile	II,III,IV	0.604	0.767	.007	23	view →
GBM	OS	Tertile	All	0.297	0.519	<.001	21	view →
PRAD	DFS	Median	All	0.685	0.889	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DBNL–ACC (DFS)

Open the ACC breakdown →