DBNL

Across TCGA patient cohorts, DBNL protein abundance is significantly associated with the RNA expression of many other genes, with 15,776 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DBNL-associated genes across cancer lineages are ARHGDIB, CCM2, and C3. Each is linked with DBNL in more than 5 cancer types. Because this analysis shows association rather than direction, both DBNL-to-partner and partner-to-DBNL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DBNL versus ARHGDIB in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBNL→partner) and Y-score (partner→DBNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGDIB →	+0.959	+0.345	<.001	<.001	3	6
LUAD	CCM2 →	+0.552	+0.125	<.001	.007	3	6
UCEC	C3 →	+1.306	+0.179	.002	<.001	3	5
BRCA	ARHGEF6 →	+0.907	+0.205	<.001	<.001	3	5
BRCA	CAB39 →	+0.421	+0.137	<.001	<.001	3	5
BRCA	RTN1 →	+0.808	+0.183	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,776 associations by consensus.

DBNL vs ARHGDIB — OV

Explore this scatter interactively →