DBNL

Across TCGA patient cohorts, DBNL mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBNL-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Fibronectin. Each is linked with DBNL in more than 1 cancer types. Because this analysis shows association rather than direction, both DBNL-to-partner and partner-to-DBNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DBNL-low versus DBNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBNL→partner) and Y-score (partner→DBNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.287	-2.584	.014	.011	3	1
UCEC	ERK2 →	+0.221	+3.459	.013	.005	3	1
UCEC	Fibronectin →	-0.349	-2.584	.023	.011	3	1
UCEC	PEA-15_pS116 →	+0.321	+3.169	.049	.019	3	1
UCEC	ATM →	-0.550	-2.321	.009	.034	3	1
UCEC	PAI-1 →	-0.327	-2.584	.041	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by DBNL expression — UCEC

Explore this box plot interactively →