DBNL

Across TCGA cell cohorts, DBNL mutation is significantly associated with the mutation status of many other genes, with 3,869 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBNL-associated genes across cancer lineages are CWF19L2, MYO15A, and PRRC2A. Each is linked with DBNL in more than 3 cancer types. Because this analysis shows association rather than direction, both DBNL-to-partner and partner-to-DBNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWF19L2 grouped by DBNL-low versus DBNL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBNL→partner) and Y-score (partner→DBNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CWF19L2 →	+4.392	+4.392	.009	.009	1	4
LARGE_INTESTINE	MYO15A →	+1.637	+3.823	<.001	<.001	1	4
LARGE_INTESTINE	PRRC2A →	+1.807	+2.584	.005	.005	1	4
PANCREAS	TNK2 →	+5.115	+5.115	.005	.005	1	3
PANCREAS	NBEA →	+5.115	+5.115	.005	.005	1	3
PANCREAS	SLX4 →	+5.115	+5.115	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,869 associations by consensus.

CWF19L2 by DBNL expression — SKIN

Explore this box plot interactively →