DBNL

Across TCGA cell cohorts, DBNL mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBNL-associated genes across cancer lineages are Alisertib, CP724714, and Masitinib. Each is linked with DBNL in more than 1 cancer types. Because this analysis shows association rather than direction, both DBNL-to-partner and partner-to-DBNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alisertib grouped by DBNL-low versus DBNL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBNL→partner) and Y-score (partner→DBNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Alisertib →	+0.911	+2.868	.007	.022	3	1
LARGE_INTESTINE	CP724714 →	+0.350	+2.652	.037	.045	3	1
LARGE_INTESTINE	Masitinib →	+0.447	+2.652	.038	.045	3	1
LARGE_INTESTINE	TPCA-1 →	+0.482	+2.786	.044	.037	3	1
LARGE_INTESTINE	ETP-45835 →	+0.246	+2.652	.042	.045	3	1
LARGE_INTESTINE	Staurosporine →	+0.527	+2.868	.017	.022	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Alisertib by DBNL expression — LARGE_INTESTINE

Explore this box plot interactively →