DBNDD1

Across TCGA pan-cancer cohorts, DBNDD1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DBNDD1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DBNDD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DBNDD1 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

COAD, LUAD, and KIRP are the cancer types where DBNDD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DBNDD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+2.302	<.001	11	view →
LUAD	Female	III,IV	+2.264	<.001	11	view →
KIRP	All	II,III,IV	+1.611	<.001	11	view →
HNSC	Female	IV	−2.083	<.001	10	view →
LIHC	Female	All	+2.062	<.001	8	view →
BRCA	All	III,IV	+1.548	<.001	8	view →
BLCA	All	All	+1.416	.005	8	view →
THCA	All	All	+0.352	<.001	7	view →
UCEC	All	All	+2.560	<.001	6	view →
READ	All	II,III,IV	+2.150	.001	6	view →
STAD	Male	II,III,IV	+1.405	.008	6	view →
LUSC	All	All	+0.617	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DBNDD1–COAD

Open the COAD breakdown →