DBN1

Across TCGA patient cohorts, DBN1 mutation is significantly associated with the RNA expression of many other genes, with 4,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBN1-associated genes across cancer lineages are MIR196A2, RNU6ATAC30P, and RNU6-776P. Each is linked with DBN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DBN1-to-partner and partner-to-DBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR196A2 grouped by DBN1-low versus DBN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBN1→partner) and Y-score (partner→DBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR196A2 →	+0.437	+3.091	<.001	.007	3	4
CESC	RNU6ATAC30P →	+0.355	+4.006	.003	.006	3	3
LIHC	RNU6-776P →	+0.322	+5.902	<.001	.001	3	3
LUAD	CYCTP →	+0.257	+6.197	<.001	.001	3	3
UCEC	LINC02485 →	+0.111	+1.263	.001	.005	3	3
LUSC	KNOP1P1 →	+0.131	+4.626	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,020 associations by consensus.

MIR196A2 by DBN1 expression — LUSC

Explore this box plot interactively →