DBI

Across TCGA patient cohorts, DBI mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBI-associated genes across cancer lineages are EGFR_pY1068, GATA6, and PCNA. Each is linked with DBI in more than 1 cancer types. Because this analysis shows association rather than direction, both DBI-to-partner and partner-to-DBI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DBI-low versus DBI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBI→partner) and Y-score (partner→DBI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-3.169	.032	.020	3	1
UCEC	GATA6 →	-0.211	-3.162	.012	.019	2	2
UCEC	PCNA →	+0.354	+3.000	.002	.036	3	1
UCEC	Smad3 →	+0.217	+3.169	.008	.020	3	1
UCEC	Ku80 →	+0.392	+3.183	.002	.010	2	1
UCEC	c-Met_pY1235 →	+0.118	+3.169	.003	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by DBI expression — UCEC

Explore this box plot interactively →