DBI

Across TCGA pan-cancer cohorts, DBI RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DBI data layer compared with 7 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DBI RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DBI expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

ACC, UCS, and KICH are the cancer types where DBI RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.747	0.950	<.001	92	view →
UCS	DFS	Median	IV	0.367	0.952	.001	78	view →
KICH	OS	Median	II,III,IV	0.630	1.000	<.001	70	view →
UVM	DFS	Tertile	III,IV	0.333	0.880	.002	40	view →
LGG	OS	Tertile	All	0.735	0.898	<.001	32	view →
STAD	DFS	Median	III,IV	0.453	0.704	.006	27	view →
LIHC	OS	Median	All	0.704	0.846	<.001	26	view →
KIRC	DFS	Quartile	All	0.785	0.947	<.001	26	view →
LUSC	OS	Median	II,III,IV	0.672	0.316	.016	25	view →
MESO	OS	Tertile	All	0.211	0.450	.003	19	view →
SKCM	OS	Quartile	III,IV	0.561	0.301	.004	14	view →
THCA	OS	Median	III,IV	1.000	0.946	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DBI–ACC (OS)

Open the ACC breakdown →