DBH

Across TCGA patient cohorts, DBH mutation is significantly associated with the RNA expression of many other genes, with 2,181 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DBH-associated genes across cancer lineages are WDR76, LINC01392, and MIR1266. Each is linked with DBH in more than 2 cancer types. Because this analysis shows association rather than direction, both DBH-to-partner and partner-to-DBH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR76 grouped by DBH-low versus DBH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBH→partner) and Y-score (partner→DBH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	WDR76 →	+0.633	+1.970	<.001	.002	3	3
LGG	LINC01392 →	+0.232	+4.620	.009	.004	3	3
STAD	MIR1266 →	+0.451	+3.773	.006	.005	3	3
SKCM	ZNF430 →	+0.563	+2.379	<.001	<.001	3	3
SKCM	ARPP19 →	+0.625	+2.813	<.001	<.001	3	3
SKCM	MAPK6 →	+0.669	+1.932	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,181 associations by consensus.

WDR76 by DBH expression — SKCM

Explore this box plot interactively →