DBET

Across TCGA patient cohorts, DBET RNA expression is significantly associated with the go_rna of many other GO terms, with 4,940 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DBET-associated GO terms across cancer lineages are tRNA thio-modification, Synaptic vesicle endosomal processing, and Ribosome-associated ubiquitin-dependent protein catabolic process. Each is linked with DBET in more than 9 cancer types. Because this analysis shows association rather than direction, both DBET-to-partner and partner-to-DBET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA thio-modification grouped by DBET-low versus DBET-high in READ.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DBET→partner) and Y-score (partner→DBET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	tRNA thio-modification →	+0.073	+0.228	<.001	<.001	3	10
READ	Synaptic vesicle endosomal processing →	-0.052	-0.245	<.001	<.001	3	9
READ	Ribosome-associated ubiquitin-dependent protein catabolic process →	-0.047	-0.207	<.001	<.001	3	9
READ	Sertoli cell development →	-0.036	-0.170	<.001	<.001	3	8
STAD	Nucleoside triphosphate biosynthetic process →	+0.058	+0.032	<.001	.008	2	9
STAD	rRNA pseudouridine synthesis →	+0.028	+0.024	<.001	.005	1	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,940 associations by consensus.

tRNA thio-modification by DBET expression — READ

Explore this box plot interactively →