DAZL

Across TCGA pan-cancer cohorts, DAZL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DAZL data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DAZL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DAZL expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where DAZL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.268	1.000	.010	12	view →
PDAC	DFS	Median	IV	0.245	0.741	.038	8	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.799	.017	5	view →
LSCC	DFS	Median	All	0.370	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DAZL–UCEC (DFS)

Open the UCEC breakdown →