DAZL

Across TCGA pan-cancer cohorts, DAZL RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DAZL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DAZL RNA is repressed in tumor relative to normal tissue. In most cancer types DAZL is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where DAZL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DAZL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.108	<.001	7	view →
KICH	All	All	−0.191	.001	5	view →
LUAD	All	II,III,IV	+0.081	.001	5	view →
LUSC	Male	All	+0.122	<.001	4	view →
BRCA	Female	II,III,IV	+0.069	.004	4	view →
HNSC	Female	II,III,IV	+0.044	<.001	3	view →
BLCA	Male	All	+0.043	.044	2	view →
THCA	All	All	−0.038	.046	2	view →
CHOL	Female	All	+0.086	.022	1	view →
COAD	Female	II,III,IV	+0.046	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DAZL–KIRC

Open the KIRC breakdown →