DAZL

Across TCGA patient cohorts, DAZL mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAZL-associated genes across cancer lineages are MAPK_pT202_Y204, NDRG1_pT346, and PCNA. Each is linked with DAZL in more than 1 cancer types. Because this analysis shows association rather than direction, both DAZL-to-partner and partner-to-DAZL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by DAZL-low versus DAZL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAZL→partner) and Y-score (partner→DAZL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.432	-2.102	.007	.016	3	2
UCEC	NDRG1_pT346 →	-0.344	-1.440	.043	.024	3	2
UCEC	PCNA →	+0.177	+1.874	.018	.049	3	2
UCEC	eEF2 →	+0.287	+1.440	.020	.024	3	1
UCEC	EGFR_pY1068 →	-0.265	-2.070	.002	.001	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MAPK_pT202_Y204 by DAZL expression — UCEC

Explore this box plot interactively →