DAZL

Across TCGA cell cohorts, DAZL mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAZL-associated genes across cancer lineages are CILP, RBM46, and TLX3. Each is linked with DAZL in more than 1 cancer types. Because this analysis shows association rather than direction, both DAZL-to-partner and partner-to-DAZL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CILP grouped by DAZL-low versus DAZL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAZL→partner) and Y-score (partner→DAZL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CILP →	+0.123	+3.706	.006	.002	3	1
LARGE_INTESTINE	RBM46 →	+0.237	+2.994	<.001	.006	3	1
LARGE_INTESTINE	TLX3 →	+0.443	+2.845	<.001	.009	3	1
LARGE_INTESTINE	SPIC →	+0.177	+2.925	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACER1 →	+0.075	+3.145	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CILP by DAZL expression — LARGE_INTESTINE

Explore this box plot interactively →