Across TCGA patient cohorts, DAXX protein abundance is significantly associated with the RNA expression of many other genes, with 11,678 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DAXX-associated genes across cancer lineages are DEK, MCM3, and TCF19. Each is linked with DAXX in more than 8 cancer types. Because this analysis shows association rather than direction, both DAXX-to-partner and partner-to-DAXX results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAXX→partner) and Y-score (partner→DAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DEK →	+0.830	+0.368	<.001	<.001	3	9
HNSC	MCM3 →	+1.053	+0.197	<.001	<.001	3	8
HNSC	TCF19 →	+1.186	+0.251	<.001	<.001	3	8
HNSC	PRIM2 →	+0.714	+0.281	<.001	<.001	3	8
OV	PFDN6 →	+0.595	+0.254	<.001	<.001	3	8
HNSC	NELFE →	+1.083	+0.225	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,678 associations by consensus.

Exploration

DAXX survival (RNA) · tumor vs normal (RNA) · all DAXX data types