Across TCGA pan-cancer cohorts, DAXX RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DAXX’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DAXX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DAXX is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
HNSC, KIRC, and KIRP are the cancer types where DAXX tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DAXX RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.