Across TCGA patient cohorts, DAXX mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAXX-associated genes across cancer lineages are 4E-BP1, Annexin-1, and Transglutaminase. Each is linked with DAXX in more than 2 cancer types. Because this analysis shows association rather than direction, both DAXX-to-partner and partner-to-DAXX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAXX→partner) and Y-score (partner→DAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.208	+2.999	.041	.035	3	3
UCEC	Annexin-1 →	+0.708	+3.827	<.001	<.001	3	2
COAD	Transglutaminase →	+0.332	+2.815	.003	.036	3	2
COAD	Chk1 →	+0.478	+2.815	<.001	.036	3	2
SKCM	EGFR →	-0.186	-3.459	.022	.005	3	2
UCEC	EGFR_pY1068 →	-0.218	-2.169	.020	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

DAXX survival (RNA) · tumor vs normal (RNA) · all DAXX data types