Across TCGA cell cohorts, DAXX mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DAXX-associated genes across cancer lineages are OR10R2, GKN2, and IFNA13. Each is linked with DAXX in more than 1 cancer types. Because this analysis shows association rather than direction, both DAXX-to-partner and partner-to-DAXX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAXX→partner) and Y-score (partner→DAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+2.105	+5.551	<.001	<.001	3	2
STOMACH	GKN2 →	+0.683	+3.700	.005	.003	3	1
STOMACH	IFNA13 →	+0.039	+3.209	.004	.007	3	1
LUNG_SCLC	TRIM48 →	+0.040	+4.269	.005	.005	3	1
LUNG_SCLC	C8orf74 →	+0.107	+4.044	<.001	.009	3	1
LUNG_SCLC	XAGE5 →	+1.584	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

DAXX survival (RNA) · tumor vs normal (RNA) · all DAXX data types