DAPL1

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DAPL1 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPL1-associated genes across cancer lineages are Macrophages M1 and aDC. Each is linked with DAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAPL1-to-partner and partner-to-DAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages M1 grouped by DAPL1-low versus DAPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPL1→partner) and Y-score (partner→DAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMacrophages M1 →+0.030+3.328.001.01231
UCECaDC →+0.097+2.818.032.03711
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Macrophages M1 by DAPL1 expression — UCEC

Box plot of Macrophages M1 in DAPL1-low vs DAPL1-high samples in UCEC.

Explore this box plot interactively →

Exploration