DAP3

Across TCGA patient cohorts, DAP3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAP3-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with DAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAP3-to-partner and partner-to-DAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DAP3-low versus DAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAP3→partner) and Y-score (partner→DAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.194	+3.000	.049	.036	3	1
UCEC	MEK1 →	+0.430	+2.584	.011	.011	3	1
UCEC	MSH2 →	-0.330	-2.973	.002	.035	3	1
UCEC	PDK1_pS241 →	+0.180	+1.887	.024	.031	3	1
UCEC	TIGAR →	+0.193	+1.901	.006	.031	3	1
UCEC	Caspase-8 →	-0.276	-2.973	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eIF4E by DAP3 expression — UCEC

Explore this box plot interactively →