DAP3

Across TCGA pan-cancer cohorts, DAP3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DAP3 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DAP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DAP3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

KIRP, ACC, and LIHC are the cancer types where DAP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.845	0.967	<.001	103	view →
ACC	DFS	Median	All	0.209	0.709	<.001	100	view →
LIHC	OS	Median	All	0.606	0.767	<.001	67	view →
KICH	OS	Tertile	All	0.405	1.000	<.001	57	view →
KIRC	DFS	Median	IV	0.507	0.718	.004	39	view →
LGG	OS	Median	All	0.755	0.867	<.001	36	view →
CESC	DFS	Tertile	All	0.720	0.879	.001	34	view →
MESO	OS	Tertile	All	0.420	0.707	.001	33	view →
UVM	OS	Median	All	0.487	0.853	.009	31	view →
THYM	DFS	Median	All	0.658	0.965	.003	29	view →
ESCA	DFS	Tertile	III,IV	0.323	0.571	.013	14	view →
PAAD	DFS	Median	All	0.203	0.381	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DAP3–KIRP (DFS)

Open the KIRP breakdown →