DAO

Across TCGA cell cohorts, DAO mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DAO-associated genes across cancer lineages are VN1R4, LIM2, and UGT2B10. Each is linked with DAO in more than 1 cancer types. Because this analysis shows association rather than direction, both DAO-to-partner and partner-to-DAO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by DAO-low versus DAO-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAO→partner) and Y-score (partner→DAO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
BLOOD_Leukemia	LIM2 →	+0.035	+5.201	<.001	.006	3	1
BLOOD_Leukemia	UGT2B10 →	+0.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR10A3 →	+0.065	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR2T1 →	+0.049	+5.539	<.001	.003	3	1
BLOOD_Leukemia	NLRP8 →	+0.102	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

VN1R4 by DAO expression — CNS

Explore this box plot interactively →