DAND5

Across TCGA pan-cancer cohorts, DAND5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DAND5 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher DAND5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DAND5 expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

KICH, KIRP, and KIRC are the cancer types where DAND5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.622	1.000	<.001	87	view →
KIRP	DFS	Median	II,III,IV	0.330	0.690	<.001	69	view →
KIRC	OS	Median	All	0.553	0.698	.001	62	view →
LIHC	DFS	Tertile	All	0.457	0.639	<.001	48	view →
LGG	DFS	Tertile	All	0.554	0.293	<.001	41	view →
MESO	OS	Tertile	II,III,IV	0.199	0.451	.001	36	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	33	view →
PAAD	OS	Median	All	0.292	0.606	<.001	27	view →
UCEC	DFS	Median	IV	0.715	0.235	.002	24	view →
CHOL	DFS	Median	All	0.246	0.698	.003	24	view →
GBM	OS	Tertile	All	0.534	0.313	.001	18	view →
UVM	DFS	Tertile	II,III,IV	0.363	0.767	.016	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DAND5–KICH (OS)

Open the KICH breakdown →