DAND5

Across TCGA pan-cancer cohorts, DAND5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DAND5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where DAND5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DAND5 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where DAND5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DAND5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.235	<.001	11	view →
KIRC	Male	III,IV	+0.258	<.001	9	view →
HNSC	All	All	+0.110	.002	8	view →
COAD	Male	II,III,IV	−1.117	<.001	7	view →
LIHC	All	II,III,IV	+0.287	<.001	7	view →
BRCA	All	All	+0.156	.001	6	view →
READ	All	All	−1.376	.002	5	view →
KICH	All	All	+0.523	.007	5	view →
STAD	All	All	−0.482	.004	5	view →
LUSC	Male	II,III,IV	+0.129	.010	4	view →
CHOL	All	All	+1.087	<.001	3	view →
THCA	All	IV	−0.355	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DAND5–KIRP

Open the KIRP breakdown →