DAGLA

Across TCGA patient cohorts, DAGLA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAGLA-associated genes across cancer lineages are RAD51, Shc_pY317, and ATM. Each is linked with DAGLA in more than 2 cancer types. Because this analysis shows association rather than direction, both DAGLA-to-partner and partner-to-DAGLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by DAGLA-low versus DAGLA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAGLA→partner) and Y-score (partner→DAGLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAD51 →	+0.181	+1.908	.042	.026	3	3
UCEC	Shc_pY317 →	-0.144	-2.169	.003	.003	3	3
UCEC	ATM →	-0.473	-2.058	.001	<.001	3	3
UCEC	Notch1 →	+0.188	+2.080	<.001	<.001	3	2
COAD	PCNA →	+0.244	+3.012	.036	.018	3	2
COAD	p90 RSK →	+0.268	+2.178	.030	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

RAD51 by DAGLA expression — SKCM

Explore this box plot interactively →