DAGLA

Across TCGA cell cohorts, DAGLA mutation is significantly associated with the RNA expression of many other genes, with 1,177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAGLA-associated genes across cancer lineages are FBXW10, B4GALNT2, and OR10K2. Each is linked with DAGLA in more than 1 cancer types. Because this analysis shows association rather than direction, both DAGLA-to-partner and partner-to-DAGLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by DAGLA-low versus DAGLA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAGLA→partner) and Y-score (partner→DAGLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXW10 →	+0.048	+3.630	<.001	.002	3	2
BLOOD_Lymphoma	B4GALNT2 →	+0.020	+4.754	<.001	<.001	3	2
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	2
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	2
LARGE_INTESTINE	TRMU →	+0.707	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ZC3H14 →	+0.539	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

FBXW10 by DAGLA expression — BLOOD_Leukemia

Explore this box plot interactively →