DAGLA

Across TCGA cell cohorts, DAGLA mutation is significantly associated with the mutation status of many other genes, with 5,998 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAGLA-associated genes across cancer lineages are TMEM131, TDRD6, and ADCY5. Each is linked with DAGLA in more than 5 cancer types. Because this analysis shows association rather than direction, both DAGLA-to-partner and partner-to-DAGLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM131 grouped by DAGLA-low versus DAGLA-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAGLA→partner) and Y-score (partner→DAGLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM131 →	+3.562	+4.684	.002	.002	1	6
BREAST	TDRD6 →	+2.857	+4.142	.008	.008	1	6
SKIN	ADCY5 →	+2.963	+2.736	.004	.004	1	5
BLOOD_Leukemia	FSIP2 →	+2.400	+3.358	<.001	<.001	1	5
BLOOD_Lymphoma	HYOU1 →	+3.922	+3.247	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	LRP5 →	+3.321	+3.321	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,998 associations by consensus.

TMEM131 by DAGLA expression — OVARY

Explore this box plot interactively →