DACT2

Across TCGA patient cohorts, DACT2 mutation is significantly associated with the RNA expression of many other genes, with 845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACT2-associated genes across cancer lineages are RN7SL488P, UBASH3B, and GFI1. Each is linked with DACT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DACT2-to-partner and partner-to-DACT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL488P grouped by DACT2-low versus DACT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT2→partner) and Y-score (partner→DACT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL488P →	+0.131	+3.204	<.001	.002	3	3
UCEC	UBASH3B →	+0.642	+2.815	.001	.001	3	2
UCEC	GFI1 →	+0.627	+2.346	<.001	.003	3	2
UCEC	IER5 →	+0.587	+2.502	.004	.002	3	2
UCEC	C4orf3 →	+0.511	+2.032	.004	.005	3	2
UCEC	ZNF503 →	-0.654	-2.502	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

RN7SL488P by DACT2 expression — COAD

Explore this box plot interactively →