DACT1

Across TCGA cell cohorts, DACT1 mutation is significantly associated with the RNA expression of many other genes, with 249 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DACT1-associated genes across cancer lineages are KRTAP2-4, MYH8, and OR3A1. Each is linked with DACT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACT1-to-partner and partner-to-DACT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-4 grouped by DACT1-low versus DACT1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT1→partner) and Y-score (partner→DACT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP2-4 →	+0.147	+4.930	<.001	.008	3	1
LUNG_SCLC	MYH8 →	+0.582	+3.078	.001	.008	3	1
LUNG_SCLC	OR3A1 →	+0.621	+3.938	<.001	<.001	3	1
LUNG_SCLC	MGAT4D →	+0.077	+3.070	.002	.009	3	1
LUNG_SCLC	OR3A2 →	+1.692	+3.256	<.001	.005	3	1
LUNG_SCLC	CLRN2 →	+0.017	+3.232	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

KRTAP2-4 by DACT1 expression — SOFT_TISSUE

Explore this box plot interactively →