DACH2

Across TCGA cell cohorts, DACH2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DACH2-associated genes across cancer lineages are MROH2B, TPD52L3, and REG3G. Each is linked with DACH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACH2-to-partner and partner-to-DACH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH2B grouped by DACH2-low versus DACH2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH2→partner) and Y-score (partner→DACH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MROH2B →	+0.050	+4.058	<.001	.009	3	2
CNS	TPD52L3 →	+0.051	+4.357	<.001	.004	3	2
LARGE_INTESTINE	REG3G →	+0.231	+2.518	<.001	.006	3	2
LARGE_INTESTINE	REG1B →	+1.550	+2.518	.004	.006	3	2
OVARY	OR1Q1 →	+0.133	+3.898	.009	.005	3	1
BREAST	ACTL9 →	+0.010	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MROH2B by DACH2 expression — BLOOD_Lymphoma

Explore this box plot interactively →