DACH1

Across TCGA patient cohorts, DACH1 mutation is significantly associated with the RNA expression of many other genes, with 5,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACH1-associated genes across cancer lineages are PRKRA, RPSAP35, and ZBTB8OSP1. Each is linked with DACH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DACH1-to-partner and partner-to-DACH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKRA grouped by DACH1-low versus DACH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH1→partner) and Y-score (partner→DACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRKRA →	+0.344	+1.260	.002	.009	3	4
LUAD	RPSAP35 →	+0.005	+4.094	<.001	.005	3	4
COAD	ZBTB8OSP1 →	+0.504	+4.451	.001	.001	3	3
SKCM	MIR4435-2HG →	+0.422	+1.439	.003	.003	3	3
SKCM	PAWR →	+0.528	+1.439	.006	.003	3	3
LUAD	TRAIP →	+0.617	+4.345	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,873 associations by consensus.

PRKRA by DACH1 expression — SKCM

Explore this box plot interactively →