DAB2

Across TCGA cell cohorts, DAB2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAB2-associated genes across cancer lineages are IQCF6, BPIFA1, and OR12D2. Each is linked with DAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAB2-to-partner and partner-to-DAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by DAB2-low versus DAB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAB2→partner) and Y-score (partner→DAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.168	+2.882	.001	.005	3	2
LARGE_INTESTINE	BPIFA1 →	+0.152	+2.688	<.001	.008	3	1
LARGE_INTESTINE	OR12D2 →	+0.057	+2.882	<.001	.005	3	1
OVARY	KRT72 →	+0.015	+4.865	.005	<.001	3	1
BLOOD_Lymphoma	CST11 →	+1.238	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	SLC22A24 →	+0.012	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

IQCF6 by DAB2 expression — LARGE_INTESTINE

Explore this box plot interactively →