DAB2

Across TCGA pan-cancer cohorts, DAB2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DAB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DAB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DAB2 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where DAB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DAB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+1.315	<.001	11	view →
KICH	Male	III,IV	−2.767	<.001	10	view →
LUAD	Female	All	−0.966	<.001	10	view →
THCA	All	II,III,IV	−0.913	<.001	8	view →
LUSC	All	II,III,IV	−1.321	<.001	7	view →
UCEC	All	All	−2.135	<.001	6	view →
BRCA	All	II,III,IV	−0.660	<.001	6	view →
HNSC	Female	All	+1.193	.002	4	view →
STAD	Male	II,III,IV	+1.005	.006	4	view →
LIHC	All	All	+0.581	.003	4	view →
CHOL	All	All	+2.170	<.001	3	view →
ESCA	Male	All	+2.072	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DAB2–KIRC

Open the KIRC breakdown →