DAB1

Across TCGA patient cohorts, DAB1 mutation is significantly associated with the RNA expression of many other genes, with 5,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAB1-associated genes across cancer lineages are BIRC5, RACGAP1, and CKAP2L. Each is linked with DAB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DAB1-to-partner and partner-to-DAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC5 grouped by DAB1-low versus DAB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAB1→partner) and Y-score (partner→DAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BIRC5 →	+0.906	+2.807	.009	.003	3	5
UCEC	RACGAP1 →	+0.518	+1.847	.006	<.001	3	5
LUAD	CKAP2L →	+0.896	+3.477	.001	.002	3	5
UCEC	ZBTB8OS →	+0.410	+2.839	<.001	<.001	3	5
UCEC	SNRNP40 →	+0.502	+2.147	.001	<.001	3	5
LUAD	DLGAP5 →	+0.908	+3.485	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,593 associations by consensus.

BIRC5 by DAB1 expression — LUAD

Explore this box plot interactively →