DAB1

Across TCGA cell cohorts, DAB1 mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAB1-associated genes across cancer lineages are MTRNR2L6, AGXT2, and CYB5D1. Each is linked with DAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAB1-to-partner and partner-to-DAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by DAB1-low versus DAB1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAB1→partner) and Y-score (partner→DAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	2
LUNG_NSCLC_LUAD	AGXT2 →	+0.016	+2.786	<.001	.007	3	2
LARGE_INTESTINE	CYB5D1 →	+1.024	+3.234	<.001	.004	3	2
LARGE_INTESTINE	FOXE3 →	+0.107	+2.559	<.001	.007	3	2
LARGE_INTESTINE	IPP →	+0.621	+3.364	.001	.002	3	2
LARGE_INTESTINE	PTPN4 →	+0.653	+3.295	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

MTRNR2L6 by DAB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →