DAB1

Across TCGA cell cohorts, DAB1 mutation is significantly associated with the mutation status of many other genes, with 5,877 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAB1-associated genes across cancer lineages are SYNGAP1, NFATC2, and ZMIZ1. Each is linked with DAB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DAB1-to-partner and partner-to-DAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYNGAP1 grouped by DAB1-low versus DAB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAB1→partner) and Y-score (partner→DAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SYNGAP1 →	+5.502	+5.502	.003	.003	1	6
CNS	NFATC2 →	+5.044	+5.614	.003	.003	1	5
CNS	ZMIZ1 →	+5.044	+5.614	.003	.003	1	5
LARGE_INTESTINE	USP34 →	+1.643	+3.145	<.001	<.001	1	5
BLOOD_Leukemia	PRRC2C →	+2.855	+3.025	.003	.003	1	5
UPPER_AERODIGESTIVE_TRACT	BAZ2B →	+4.392	+4.954	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,877 associations by consensus.

SYNGAP1 by DAB1 expression — LUNG_SCLC

Explore this box plot interactively →